Stabilization of Expanded (CTG)•(CAG) Repeats by Antisense Oligonucleotides

Myotonic dystrophy type 1 (DM1) is caused by expansion of a CTG repeat in the gene DMPK. The expansion is highly unstable in somatic cells, a feature that may contribute to disease progression. The RNA expressed from the mutant allele exerts a toxic gain of function, due to the presence of an expand...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Main Authors: Nakamori, Masayuki, Gourdon, Geneviève, Thornton, Charles A
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2011
Fag:
Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3242663/
https://ncbi.nlm.nih.gov/pubmed/21971425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2011.191
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker