Expanded CTG repeat demarcates a boundary for abnormal CpG methylation in myotonic dystrophy patient tissues

Myotonic dystrophy (DM1) affects multiple organs, shows age-dependent progression and is caused by CTG expansions at the DM1 locus. We determined the DM1 CpG methylation profile and CTG length in tissues from DM1 foetuses, DM1 adults, non-affected individuals and transgenic DM1 mice. Analysis includ...

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Hlavní autoři: López Castel, Arturo, Nakamori, Masayuki, Tomé, Stephanie, Chitayat, David, Gourdon, Geneviève, Thornton, Charles A., Pearson, Christopher E.
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2011
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3000673/
https://ncbi.nlm.nih.gov/pubmed/21044947
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddq427
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