Transcriptionally Repressive Chromatin Remodelling and CpG Methylation in the Presence of Expanded CTG-Repeats at the DM1 Locus

An expanded CTG-repeat in the 3′ UTR of the DMPK gene is responsible for myotonic dystrophy type I (DM1). Somatic and intergenerational instability cause the disease to become more severe during life and in subsequent generations. Evidence is accumulating that trinucleotide repeat instability and di...

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Autores principales: Brouwer, Judith Rixt, Huguet, Aline, Nicole, Annie, Munnich, Arnold, Gourdon, Geneviève
Formato: Artigo
Lenguaje:Inglês
Publicado: Hindawi Publishing Corporation 2013
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3884603/
https://ncbi.nlm.nih.gov/pubmed/24455202
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2013/567435
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