The Werner Syndrome Protein Promotes CAG/CTG Repeat Stability by Resolving Large (CAG)(n)/(CTG)(n) Hairpins

Expansion of CAG/CTG repeats causes certain neurological and neurodegenerative disorders, and the formation and subsequent persistence of stable DNA hairpins within these repeats are believed to contribute to CAG/CTG repeat instability. Human cells possess a DNA hairpin repair (HPR) pathway, which r...

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Autors principals: Chan, Nelson L. S., Hou, Caixia, Zhang, Tianyi, Yuan, Fenghua, Machwe, Amrita, Huang, Jian, Orren, David K., Gu, Liya, Li, Guo-Min
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2012
Matèries:
DNA and Chromosomes
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3436269/
https://ncbi.nlm.nih.gov/pubmed/22787159
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.389791
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