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MutSβ promotes trinucleotide repeat expansion by recruiting DNA polymerase β to nascent (CAG)(n) or (CTG)(n) hairpins for error-prone DNA synthesis
Expansion of (CAG)•(CTG) repeats causes a number of familial neurodegenerative disorders. Although the underlying mechanism remains largely unknown, components involved in DNA mismatch repair, particularly mismatch recognition protein MutSβ (a MSH2-MSH3 heterodimer), are implicated in (CAG)•(CTG) re...
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| Publicado no: | Cell Res |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5129881/ https://ncbi.nlm.nih.gov/pubmed/27255792 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cr.2016.66 |
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