MutSβ promotes trinucleotide repeat expansion by recruiting DNA polymerase β to nascent (CAG)(n) or (CTG)(n) hairpins for error-prone DNA synthesis

Expansion of (CAG)•(CTG) repeats causes a number of familial neurodegenerative disorders. Although the underlying mechanism remains largely unknown, components involved in DNA mismatch repair, particularly mismatch recognition protein MutSβ (a MSH2-MSH3 heterodimer), are implicated in (CAG)•(CTG) re...

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Bibliographic Details
Published in:Cell Res
Main Authors: Guo, Jinzhen, Gu, Liya, Leffak, Michael, Li, Guo-Min
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2016
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5129881/
https://ncbi.nlm.nih.gov/pubmed/27255792
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cr.2016.66
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