Molecular basis of the dual role of the Mlh1-Mlh3 endonuclease in MMR and in meiotic crossover formation

In budding yeast, the MutL homolog heterodimer Mlh1-Mlh3 (MutLγ) plays a central role in the formation of meiotic crossovers. It is also involved in the repair of a subset of mismatches besides the main mismatch repair (MMR) endonuclease Mlh1-Pms1 (MutLα). The heterodimer interface and endonuclease...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Dai, Jingqi, Sanchez, Aurore, Adam, Céline, Ranjha, Lepakshi, Reginato, Giordano, Chervy, Pierre, Tellier-Lebegue, Carine, Andreani, Jessica, Guérois, Raphaël, Ropars, Virginie, Le Du, Marie-Hélène, Maloisel, Laurent, Martini, Emmanuelle, Legrand, Pierre, Thureau, Aurélien, Cejka, Petr, Borde, Valérie, Charbonnier, Jean-Baptiste
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2021
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8201911/
https://ncbi.nlm.nih.gov/pubmed/34088835
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2022704118
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