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The Saccharomyces cerevisiae Mlh1-Mlh3 Heterodimer Is an Endonuclease That Preferentially Binds to Holliday Junctions

MutLγ, a heterodimer of the MutL homologues Mlh1 and Mlh3, plays a critical role during meiotic homologous recombination. The meiotic function of Mlh3 is fully dependent on the integrity of a putative nuclease motif DQHAX(2)EX(4)E, inferring that the anticipated nuclease activity of Mlh1-Mlh3 is inv...

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Bibliografiska uppgifter
Huvudupphovsmän: Ranjha, Lepakshi, Anand, Roopesh, Cejka, Petr
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Biochemistry and Molecular Biology 2014
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3937642/
https://ncbi.nlm.nih.gov/pubmed/24443562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.533810
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