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The Saccharomyces cerevisiae Mlh1-Mlh3 Heterodimer Is an Endonuclease That Preferentially Binds to Holliday Junctions
MutLγ, a heterodimer of the MutL homologues Mlh1 and Mlh3, plays a critical role during meiotic homologous recombination. The meiotic function of Mlh3 is fully dependent on the integrity of a putative nuclease motif DQHAX(2)EX(4)E, inferring that the anticipated nuclease activity of Mlh1-Mlh3 is inv...
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| Auteurs principaux: | , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American Society for Biochemistry and Molecular Biology
2014
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3937642/ https://ncbi.nlm.nih.gov/pubmed/24443562 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.533810 |
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