CD70-specific CAR T cells have potent activity against acute myeloid leukemia without HSC toxicity

The prognosis of patients with acute myeloid leukemia (AML) remains dismal, highlighting the need for novel innovative treatment strategies. The application of chimeric antigen receptor (CAR) T-cell therapy to patients with AML has been limited, in particular by the lack of a tumor-specific target a...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Blood
Main Authors: Sauer, Tim, Parikh, Kathan, Sharma, Sandhya, Omer, Bilal, Sedloev, David, Chen, Qian, Angenendt, Linus, Schliemann, Christoph, Schmitt, Michael, Müller-Tidow, Carsten, Gottschalk, Stephen, Rooney, Cliona M.
Format: Artigo
Jezik:Inglês
Izdano: American Society of Hematology 2021
Teme:
Immunobiology and Immunotherapy
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC8323977/
https://ncbi.nlm.nih.gov/pubmed/34323938
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2020008221
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