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CD70-specific CAR T cells have potent activity against acute myeloid leukemia without HSC toxicity

The prognosis of patients with acute myeloid leukemia (AML) remains dismal, highlighting the need for novel innovative treatment strategies. The application of chimeric antigen receptor (CAR) T-cell therapy to patients with AML has been limited, in particular by the lack of a tumor-specific target a...

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Dettagli Bibliografici
Pubblicato in:Blood
Autori principali: Sauer, Tim, Parikh, Kathan, Sharma, Sandhya, Omer, Bilal, Sedloev, David, Chen, Qian, Angenendt, Linus, Schliemann, Christoph, Schmitt, Michael, Müller-Tidow, Carsten, Gottschalk, Stephen, Rooney, Cliona M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Hematology 2021
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8323977/
https://ncbi.nlm.nih.gov/pubmed/34323938
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2020008221
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