CD70-specific CAR T cells have potent activity against acute myeloid leukemia without HSC toxicity

The prognosis of patients with acute myeloid leukemia (AML) remains dismal, highlighting the need for novel innovative treatment strategies. The application of chimeric antigen receptor (CAR) T-cell therapy to patients with AML has been limited, in particular by the lack of a tumor-specific target a...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Sauer, Tim, Parikh, Kathan, Sharma, Sandhya, Omer, Bilal, Sedloev, David, Chen, Qian, Angenendt, Linus, Schliemann, Christoph, Schmitt, Michael, Müller-Tidow, Carsten, Gottschalk, Stephen, Rooney, Cliona M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2021
Assuntos:
Immunobiology and Immunotherapy
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8323977/
https://ncbi.nlm.nih.gov/pubmed/34323938
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2020008221
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