CAR-modified memory-like NK cells exhibit potent responses to NK-resistant lymphomas

Natural killer (NK) cells are a promising cellular immunotherapy for cancer. Cytokine-induced memory-like (ML) NK cells differentiate after activation with interleukin-12 (IL-12), IL-15, and IL-18, exhibit potent antitumor responses, and safely induce complete remissions in patients with leukemia. H...

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Bibliographische Detailangaben
Veröffentlicht in:Blood
Hauptverfasser: Gang, Margery, Marin, Nancy D., Wong, Pamela, Neal, Carly C., Marsala, Lynne, Foster, Mark, Schappe, Timothy, Meng, Wei, Tran, Jennifer, Schaettler, Maximilian, Davila, Marco, Gao, Feng, Cashen, Amanda F., Bartlett, Nancy L., Mehta-Shah, Neha, Kahl, Brad S., Kim, Miriam Y., Cooper, Matthew L., DiPersio, John F., Berrien-Elliott, Melissa M., Fehniger, Todd A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Hematology 2020
Schlagworte:
Immunobiology and Immunotherapy
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7702478/
https://ncbi.nlm.nih.gov/pubmed/32614951
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2020006619
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