BRCA2 binding through a cryptic repeated motif to HSF2BP oligomers does not impact meiotic recombination

BRCA2 and its interactors are required for meiotic homologous recombination (HR) and fertility. Loss of HSF2BP, a BRCA2 interactor, disrupts HR during spermatogenesis. We test the model postulating that HSF2BP localizes BRCA2 to meiotic HR sites, by solving the crystal structure of the BRCA2 fragmen...

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Publicado no:Nat Commun
Main Authors: Ghouil, Rania, Miron, Simona, Koornneef, Lieke, Veerman, Jasper, Paul, Maarten W., Le Du, Marie-Hélène, Sleddens-Linkels, Esther, van Rossum-Fikkert, Sari E., van Loon, Yvette, Felipe-Medina, Natalia, Pendas, Alberto M., Maas, Alex, Essers, Jeroen, Legrand, Pierre, Baarends, Willy M., Kanaar, Roland, Zinn-Justin, Sophie, Zelensky, Alex N.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8322138/
https://ncbi.nlm.nih.gov/pubmed/34326328
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-24871-6
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