Caffeine suppresses homologous recombination through interference with RAD51-mediated joint molecule formation

Caffeine is a widely used inhibitor of the protein kinases that play a central role in the DNA damage response. We used chemical inhibitors and genetically deficient mouse embryonic stem cell lines to study the role of DNA damage response in stable integration of the transfected DNA and found that c...

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Autors principals: Zelensky, Alex N., Sanchez, Humberto, Ristic, Dejan, Vidic, Iztok, van Rossum-Fikkert, Sari E., Essers, Jeroen, Wyman, Claire, Kanaar, Roland
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2013
Matèries:
Genome Integrity, Repair and Replication
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3711438/
https://ncbi.nlm.nih.gov/pubmed/23666627
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt375
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