Caffeine suppresses homologous recombination through interference with RAD51-mediated joint molecule formation

Caffeine is a widely used inhibitor of the protein kinases that play a central role in the DNA damage response. We used chemical inhibitors and genetically deficient mouse embryonic stem cell lines to study the role of DNA damage response in stable integration of the transfected DNA and found that c...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Zelensky, Alex N., Sanchez, Humberto, Ristic, Dejan, Vidic, Iztok, van Rossum-Fikkert, Sari E., Essers, Jeroen, Wyman, Claire, Kanaar, Roland
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Oxford University Press 2013
Pynciau:
Genome Integrity, Repair and Replication
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3711438/
https://ncbi.nlm.nih.gov/pubmed/23666627
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt375
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