Conformational flexibility and oligomerization of BRCA2 regions induced by RAD51 interaction

BRCA2 is a key breast cancer associated protein that is predicted to have interspersed regions of intrinsic disorder. Intrinsic disorder coupled with large size likely allows BRCA2 to sample a broad range of conformational space. We expect that the resulting dynamic arrangements of BRCA2 domains are...

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Vydáno v:Nucleic Acids Res
Hlavní autoři: Sidhu, Arshdeep, Grosbart, Małgorzata, Sánchez, Humberto, Verhagen, Bram, van der Zon, Nick L L, Ristić, Dejan, van Rossum-Fikkert, Sarah E, Wyman, Claire
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2020
Témata:
Genome Integrity, Repair and Replication
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7515699/
https://ncbi.nlm.nih.gov/pubmed/32785644
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa648
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