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Effect of the BRCA2 CTRD domain on RAD51 filaments analyzed by an ensemble of single molecule techniques

Homologous recombination is essential for the preservation of genome stability, thereby preventing cancer. The recombination protein RAD51 drives DNA strand exchange, which requires the assembly, rearrangement and disassembly of a RAD51 filament on DNA, coupled to ATP binding and hydrolysis. This pr...

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Detalhes bibliográficos
Main Authors: Holthausen, J. T., van Loenhout, M. T. J., Sanchez, H., Ristic, D., van Rossum-Fikkert, S. E., Modesti, M., Dekker, C., Kanaar, R., Wyman, C.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2011
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3159462/
https://ncbi.nlm.nih.gov/pubmed/21576230
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkr295
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