Effect of the BRCA2 CTRD domain on RAD51 filaments analyzed by an ensemble of single molecule techniques

Homologous recombination is essential for the preservation of genome stability, thereby preventing cancer. The recombination protein RAD51 drives DNA strand exchange, which requires the assembly, rearrangement and disassembly of a RAD51 filament on DNA, coupled to ATP binding and hydrolysis. This pr...

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Détails bibliographiques
Auteurs principaux: Holthausen, J. T., van Loenhout, M. T. J., Sanchez, H., Ristic, D., van Rossum-Fikkert, S. E., Modesti, M., Dekker, C., Kanaar, R., Wyman, C.
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2011
Sujets:
Genome Integrity, Repair and Replication
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3159462/
https://ncbi.nlm.nih.gov/pubmed/21576230
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkr295
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