HSF2BP negatively regulates homologous recombination in DNA interstrand crosslink repair

The tumor suppressor BRCA2 is essential for homologous recombination (HR), replication fork stability and DNA interstrand crosslink (ICL) repair in vertebrates. We show that ectopic production of HSF2BP, a BRCA2-interacting protein required for meiotic HR during mouse spermatogenesis, in non-germlin...

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Detalles Bibliográficos
Publicado en:Nucleic Acids Res
Autores principales: Sato, Koichi, Brandsma, Inger, van Rossum-Fikkert, Sari E, Verkaik, Nicole, Oostra, Anneke B, Dorsman, Josephine C, van Gent, Dik C, Knipscheer, Puck, Kanaar, Roland, Zelensky, Alex N
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2020
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7049687/
https://ncbi.nlm.nih.gov/pubmed/31960047
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz1219
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