Low dose ionizing radiation strongly stimulates insertional mutagenesis in a γH2AX dependent manner

Extrachromosomal DNA can integrate into the genome with no sequence specificity producing an insertional mutation. This process, which is referred to as random integration (RI), requires a double stranded break (DSB) in the genome. Inducing DSBs by various means, including ionizing radiation, increa...

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Detalhes bibliográficos
Publicado no:PLoS Genet
Main Authors: Zelensky, Alex N., Schoonakker, Mascha, Brandsma, Inger, Tijsterman, Marcel, van Gent, Dik C., Essers, Jeroen, Kanaar, Roland
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6964834/
https://ncbi.nlm.nih.gov/pubmed/31945059
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1008550
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