Role of BRCA2 DNA-binding and C-terminal domain in its mobility and conformation in DNA repair

Breast cancer type two susceptibility protein (BRCA2) is an essential protein in genome maintenance, homologous recombination (HR), and replication fork protection. Its function includes multiple interaction partners and requires timely localization to relevant sites in the nucleus. We investigated...

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Bibliografiska uppgifter
I publikationen:eLife
Huvudupphovsmän: Paul, Maarten W, Sidhu, Arshdeep, Liang, Yongxin, van Rossum-Fikkert, Sarah E, Odijk, Hanny, Zelensky, Alex N, Kanaar, Roland, Wyman, Claire
Materialtyp: Artigo
Språk:Inglês
Publicerad: eLife Sciences Publications, Ltd 2021
Ämnen:
Biochemistry and Chemical Biology
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC8324294/
https://ncbi.nlm.nih.gov/pubmed/34254584
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.67926
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