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Role of BRCA2 DNA-binding and C-terminal domain in its mobility and conformation in DNA repair

Breast cancer type two susceptibility protein (BRCA2) is an essential protein in genome maintenance, homologous recombination (HR), and replication fork protection. Its function includes multiple interaction partners and requires timely localization to relevant sites in the nucleus. We investigated...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Paul, Maarten W, Sidhu, Arshdeep, Liang, Yongxin, van Rossum-Fikkert, Sarah E, Odijk, Hanny, Zelensky, Alex N, Kanaar, Roland, Wyman, Claire
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8324294/
https://ncbi.nlm.nih.gov/pubmed/34254584
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.67926
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