Intranasal insulin rescues repeated anesthesia-induced deficits in synaptic plasticity and memory and prevents apoptosis in neonatal mice via mTORC1

Long-lasting cognitive impairment in juveniles undergoing repeated general anesthesia has been observed in numerous preclinical and clinical studies, yet, the underlying mechanisms remain unknown and no preventive treatment is available. We found that daily intranasal insulin administration to juven...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Roque, Patricia Soriano, Hooshmandi, Mehdi, Neagu-Lund, Laura, Yin, Shelly, Yousefpour, Noosha, Sato, Hiroaki, Sato, Tamaki, Nakadate, Yosuke, Kawakami, Akiko, Tahmasebi, Soroush, Ribeiro-da-Silva, Alfredo, Gkogkas, Christos G., Prager-Khoutorsky, Masha, Schricker, Thomas, Wykes, Linda, Khoutorsky, Arkady
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8322102/
https://ncbi.nlm.nih.gov/pubmed/34326413
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-94849-3
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