Apigenin restores endothelial function by ameliorating oxidative stress, reverses aortic stiffening, and mitigates vascular inflammation with aging

We assessed the efficacy of oral supplementation with the flavanoid apigenin on arterial function during aging and identified critical mechanisms of action. Young (6 mo) and old (27 mo) C57BL/6N mice (model of arterial aging) consumed drinking water containing vehicle (0.2% carboxymethylcellulose; 1...

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Detalhes bibliográficos
Publicado no:Am J Physiol Heart Circ Physiol
Main Authors: Clayton, Zachary S., Hutton, David A., Brunt, Vienna E., VanDongen, Nicholas S., Ziemba, Brian P., Casso, Abigail G., Greenberg, Nathan T., Mercer, Amanda N., Rossman, Matthew J., Campisi, Judith, Melov, Simon, Seals, Douglas R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2021
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8321807/
https://ncbi.nlm.nih.gov/pubmed/34114892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00118.2021
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