Doxorubicin-Induced Oxidative Stress and Endothelial Dysfunction in Conduit Arteries Is Prevented by Mitochondrial-Specific Antioxidant Treatment

BACKGROUND: Doxorubicin (DOXO) chemotherapy increases risk for cardiovascular disease in part by inducing endothelial dysfunction in conduit arteries. However, the mechanisms mediating DOXO-associated endothelial dysfunction in (intact) arteries and treatment strategies are not established. OBJECTIV...

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Detalhes bibliográficos
Publicado no:JACC CardioOncol
Main Authors: Clayton, Zachary S., Brunt, Vienna E., Hutton, David A., VanDongen, Nicholas S., D’Alessandro, Angelo, Reisz, Julie A., Ziemba, Brian P., Seals, Douglas R.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2020
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7561020/
https://ncbi.nlm.nih.gov/pubmed/33073250
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaccao.2020.06.010
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