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Trimethylamine-N-Oxide Promotes Age-Related Vascular Oxidative Stress and Endothelial Dysfunction in Mice and Healthy Humans

Age-related vascular endothelial dysfunction is a major antecedent to cardiovascular diseases. We investigated whether increased circulating levels of the gut microbiome-generated metabolite trimethylamine-N-oxide induces endothelial dysfunction with aging. In healthy humans, plasma trimethylamine-N...

詳細記述

保存先:
書誌詳細
出版年:Hypertension
主要な著者: Brunt, Vienna E., Gioscia-Ryan, Rachel A., Casso, Abigail G., VanDongen, Nicholas S., Ziemba, Brian P., Sapinsley, Zachary J., Richey, James J., Zigler, Melanie C., Neilson, Andrew P., Davy, Kevin P., Seals, Douglas R.
フォーマット: Artigo
言語:Inglês
出版事項: 2020
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC7295014/
https://ncbi.nlm.nih.gov/pubmed/32520619
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/HYPERTENSIONAHA.120.14759
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