The Gut Microbiome-Derived Metabolite Trimethylamine N-Oxide Induces Aortic Stiffening and Increases Systolic Blood Pressure with Aging in Mice and Humans

Aging is associated with stiffening of the large elastic arteries and consequent increases in systolic blood pressure (SBP), which together increase cardiovascular disease risk; however, the upstream mechanisms are incompletely understood. Using complementary translational approaches in mice and hum...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Hypertension
Egile Nagusiak: Brunt, Vienna E., Casso, Abigail G., Gioscia-Ryan, Rachel A., Sapinsley, Zachary J., Ziemba, Brian P., Clayton, Zachary S., Bazzoni, Amy E., VanDongen, Nicholas S., Richey, James J., Hutton, David A., Zigler, Melanie C., Neilson, Andrew P., Davy, Kevin P., Seals, Douglas R.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2021
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC8266738/
https://ncbi.nlm.nih.gov/pubmed/33966451
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/HYPERTENSIONAHA.120.16895
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