The Gut Microbiome-Derived Metabolite Trimethylamine N-Oxide Induces Aortic Stiffening and Increases Systolic Blood Pressure with Aging in Mice and Humans

Aging is associated with stiffening of the large elastic arteries and consequent increases in systolic blood pressure (SBP), which together increase cardiovascular disease risk; however, the upstream mechanisms are incompletely understood. Using complementary translational approaches in mice and hum...

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Publicado no:Hypertension
Main Authors: Brunt, Vienna E., Casso, Abigail G., Gioscia-Ryan, Rachel A., Sapinsley, Zachary J., Ziemba, Brian P., Clayton, Zachary S., Bazzoni, Amy E., VanDongen, Nicholas S., Richey, James J., Hutton, David A., Zigler, Melanie C., Neilson, Andrew P., Davy, Kevin P., Seals, Douglas R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8266738/
https://ncbi.nlm.nih.gov/pubmed/33966451
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/HYPERTENSIONAHA.120.16895
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