The Gut Microbiome-Derived Metabolite Trimethylamine N-Oxide Induces Aortic Stiffening and Increases Systolic Blood Pressure with Aging in Mice and Humans

Aging is associated with stiffening of the large elastic arteries and consequent increases in systolic blood pressure (SBP), which together increase cardiovascular disease risk; however, the upstream mechanisms are incompletely understood. Using complementary translational approaches in mice and hum...

Full beskrivning

Sparad:
Bibliografiska uppgifter
I publikationen:Hypertension
Huvudupphovsmän: Brunt, Vienna E., Casso, Abigail G., Gioscia-Ryan, Rachel A., Sapinsley, Zachary J., Ziemba, Brian P., Clayton, Zachary S., Bazzoni, Amy E., VanDongen, Nicholas S., Richey, James J., Hutton, David A., Zigler, Melanie C., Neilson, Andrew P., Davy, Kevin P., Seals, Douglas R.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2021
Ämnen:
Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC8266738/
https://ncbi.nlm.nih.gov/pubmed/33966451
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/HYPERTENSIONAHA.120.16895
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk