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UVB mutagenesis differs in Nras- and Braf-mutant mouse models of melanoma

BRAF-mutant melanomas are more likely than NRAS-mutant melanomas to arise in anatomical locations protected from chronic sun damage. We hypothesized that this discrepancy in tumor location is a consequence of the differential sensitivity of BRAF and NRAS-mutant melanocytes to ultraviolet light (UV)-...

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Bibliographische Detailangaben
Veröffentlicht in:Life Sci Alliance
Hauptverfasser: Bowman, Robert L, Hennessey, Rebecca C, Weiss, Tirzah J, Tallman, David A, Crawford, Emma R, Murphy, Brandon M, Webb, Amy, Zhang, Souhui, La Perle, Krista MD, Burd, Craig J, Levine, Ross L, Shain, A Hunter, Burd, Christin E
Format: Artigo
Sprache:Inglês
Veröffentlicht: Life Science Alliance LLC 2021
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8321651/
https://ncbi.nlm.nih.gov/pubmed/34210801
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.26508/lsa.202101135
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