CBFB-MYH11 Fusion Sequesters RUNX1 in Cytoplasm to Prevent DNMT3A Recruitment to Target Genes in AML

A growing number of human diseases have been found to be associated with aberrant DNA methylation, including cancer. Mutations targeting genes encoding DNA methyltransferase (DNMT), TET family of DNA demethylases, and isocitrate dehydrogenase (IDH1, IDH2) that produce TET inhibitory metabolite, 2-hy...

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Detalhes bibliográficos
Publicado no:Front Cell Dev Biol
Main Authors: Liu, Peng, Liu, Jin-Pin, Sun, Si-Jia, Gao, Yun, Ai, Yingjie, Chen, Xiufei, Sun, Yiping, Zhou, Mengyu, Liu, Yun, Xiong, Yue, Yuan, Hai-Xin
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021
Assuntos:
Cell and Developmental Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8321512/
https://ncbi.nlm.nih.gov/pubmed/34336831
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcell.2021.675424
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