Structural basis of NF-κB signaling by the p75 neurotrophin receptor interaction with adaptor protein TRADD through their respective death domains

The p75 neurotrophin receptor (p75(NTR)) is a critical mediator of neuronal death and tissue remodeling and has been implicated in various neurodegenerative diseases and cancers. The death domain (DD) of p75(NTR) is an intracellular signaling hub and has been shown to interact with diverse adaptor p...

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Bibliografische gegevens
Gepubliceerd in:J Biol Chem
Hoofdauteurs: Zhang, Ning, Kisiswa, Lilian, Ramanujan, Ajeena, Li, Zhen, Sim, Eunice Weiling, Tian, Xianbin, Yuan, Wensu, Ibáñez, Carlos F., Lin, Zhi
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Biochemistry and Molecular Biology 2021
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8318917/
https://ncbi.nlm.nih.gov/pubmed/34175311
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100916
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