The Transcriptomic Landscape of Mismatch Repair-Deficient Intestinal Stem Cells

Lynch Syndrome (LS) is the most common cause of hereditary colorectal cancer (CRC) and is secondary to germline alterations in one of four DNA mismatch repair (MMR) genes. Here we aimed to provide novel insights into the initiation of MMR deficient (MMRd) colorectal carcinogenesis by characterizing...

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書誌詳細
出版年:Cancer Res
主要な著者: Bommi, Prashant V., Bowen, Charles M., Reyes-Uribe, Laura, Wu, Wenhui, Katayama, Hiroyuki, Rocha, Pedro, Parra, Edwin R., Francisco-Cruz, Alejandro, Ozcan, Zuhal, Tosti, Elena, Willis, Jason A., Wu, Hong, Taggart, Melissa W., Burks, Jared K., Lynch, Patrick M., Edelmann, Winfried, Scheet, Paul, Wistuba, Ignacio I., Sinha, Krishna M., Hanash, Samir M., Vilar, Eduardo
フォーマット: Artigo
言語:Inglês
出版事項: 2021
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC8318201/
https://ncbi.nlm.nih.gov/pubmed/34003775
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-20-2896
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