The Transcriptomic Landscape of Mismatch Repair-Deficient Intestinal Stem Cells

Lynch Syndrome (LS) is the most common cause of hereditary colorectal cancer (CRC) and is secondary to germline alterations in one of four DNA mismatch repair (MMR) genes. Here we aimed to provide novel insights into the initiation of MMR deficient (MMRd) colorectal carcinogenesis by characterizing...

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Publicado no:Cancer Res
Main Authors: Bommi, Prashant V., Bowen, Charles M., Reyes-Uribe, Laura, Wu, Wenhui, Katayama, Hiroyuki, Rocha, Pedro, Parra, Edwin R., Francisco-Cruz, Alejandro, Ozcan, Zuhal, Tosti, Elena, Willis, Jason A., Wu, Hong, Taggart, Melissa W., Burks, Jared K., Lynch, Patrick M., Edelmann, Winfried, Scheet, Paul, Wistuba, Ignacio I., Sinha, Krishna M., Hanash, Samir M., Vilar, Eduardo
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8318201/
https://ncbi.nlm.nih.gov/pubmed/34003775
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-20-2896
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