The Transcriptomic Landscape of Mismatch Repair-Deficient Intestinal Stem Cells

Lynch Syndrome (LS) is the most common cause of hereditary colorectal cancer (CRC) and is secondary to germline alterations in one of four DNA mismatch repair (MMR) genes. Here we aimed to provide novel insights into the initiation of MMR deficient (MMRd) colorectal carcinogenesis by characterizing...

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Bibliografske podrobnosti
izdano v:Cancer Res
Main Authors: Bommi, Prashant V., Bowen, Charles M., Reyes-Uribe, Laura, Wu, Wenhui, Katayama, Hiroyuki, Rocha, Pedro, Parra, Edwin R., Francisco-Cruz, Alejandro, Ozcan, Zuhal, Tosti, Elena, Willis, Jason A., Wu, Hong, Taggart, Melissa W., Burks, Jared K., Lynch, Patrick M., Edelmann, Winfried, Scheet, Paul, Wistuba, Ignacio I., Sinha, Krishna M., Hanash, Samir M., Vilar, Eduardo
Format: Artigo
Jezik:Inglês
Izdano: 2021
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC8318201/
https://ncbi.nlm.nih.gov/pubmed/34003775
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-20-2896
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