Delineating the Ligand–Receptor Interactions That Lead to Biased Signaling at the μ-Opioid Receptor

[Image: see text] Biased agonists, which selectively stimulate certain signaling pathways controlled by a G protein-coupled receptor (GPCR), hold great promise as drugs that maximize efficacy while minimizing dangerous side effects. Biased agonists of the μ-opioid receptor (μOR) are of particular in...

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Publié dans:J Chem Inf Model
Auteurs principaux: Kelly, Brendan, Hollingsworth, Scott A., Blakemore, David C., Owen, Robert M., Storer, R. Ian, Swain, Nigel A., Aydin, Deniz, Torella, Rubben, Warmus, Joseph S., Dror, Ron O.
Format: Artigo
Langue:Inglês
Publié: American Chemical Society 2021
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8317888/
https://ncbi.nlm.nih.gov/pubmed/34251810
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jcim.1c00585
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