Tumor Immune Profiling-Based Neoadjuvant Immunotherapy for Locally Advanced Melanoma

BACKGROUND. The frequency of "exhausted" or check-point-positive (PD-1(+)CTLA-4(+)) cytotoxic lymphocytes (Tex) in the tumor microenvironment is associated with response to anti-PD-1 therapy in metastatic melanoma. The current study determined whether pretreatment Tex cells in locally adva...

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Dades bibliogràfiques
Publicat a:Ann Surg Oncol
Autors principals: Levine, Lauren S., Mahuron, Kelly M., Tsai, Katy K., Wu, Clinton, Mattis, Daiva M., Pauli, Mariela L., Oglesby, Arielle, Lee, James C., Spitzer, Matthew H., Krummel, Matthew F., Algazi, Alain P., Rosenblum, Michael D., Alvarado, Michael, Daud, Adil I.
Format: Artigo
Idioma:Inglês
Publicat: 2020
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8317618/
https://ncbi.nlm.nih.gov/pubmed/32488521
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1245/s10434-020-08648-7
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