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Partially exhausted tumor-infiltrating lymphocytes predict response to combination immunotherapy
BACKGROUND. Programmed death 1 (PD-1) inhibition activates partially exhausted cytotoxic T lymphocytes (peCTLs) and induces tumor regression. We previously showed that the peCTL fraction predicts response to anti–PD-1 monotherapy. Here, we sought to correlate peCTL and regulatory T lymphocyte (Treg)...
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Publicado no: | JCI Insight |
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Main Authors: | , , , , , , , , , , , , , , , |
Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
American Society for Clinical Investigation
2017
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5518562/ https://ncbi.nlm.nih.gov/pubmed/28724802 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.93433 |
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