Partially exhausted tumor-infiltrating lymphocytes predict response to combination immunotherapy

BACKGROUND. Programmed death 1 (PD-1) inhibition activates partially exhausted cytotoxic T lymphocytes (peCTLs) and induces tumor regression. We previously showed that the peCTL fraction predicts response to anti–PD-1 monotherapy. Here, we sought to correlate peCTL and regulatory T lymphocyte (Treg)...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:JCI Insight
Päätekijät: Loo, Kimberly, Tsai, Katy K., Mahuron, Kelly, Liu, Jacqueline, Pauli, Mariela L., Sandoval, Priscila M., Nosrati, Adi, Lee, James, Chen, Lawrence, Hwang, Jimmy, Levine, Lauren S., Krummel, Matthew F., Algazi, Alain P., Alvarado, Michael D, Rosenblum, Michael D., Daud, Adil I.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Clinical Investigation 2017
Aiheet:
Clinical Medicine
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5518562/
https://ncbi.nlm.nih.gov/pubmed/28724802
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.93433
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