Partially exhausted tumor-infiltrating lymphocytes predict response to combination immunotherapy

BACKGROUND. Programmed death 1 (PD-1) inhibition activates partially exhausted cytotoxic T lymphocytes (peCTLs) and induces tumor regression. We previously showed that the peCTL fraction predicts response to anti–PD-1 monotherapy. Here, we sought to correlate peCTL and regulatory T lymphocyte (Treg)...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Loo, Kimberly, Tsai, Katy K., Mahuron, Kelly, Liu, Jacqueline, Pauli, Mariela L., Sandoval, Priscila M., Nosrati, Adi, Lee, James, Chen, Lawrence, Hwang, Jimmy, Levine, Lauren S., Krummel, Matthew F., Algazi, Alain P., Alvarado, Michael D, Rosenblum, Michael D., Daud, Adil I.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2017
Assuntos:
Clinical Medicine
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5518562/
https://ncbi.nlm.nih.gov/pubmed/28724802
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.93433
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