Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries

Current methods used for measuring amino acid side-chain reactivity lack the throughput needed to screen large chemical libraries for interactions across the proteome. Here we redesigned the workflow for activity-based protein profiling of reactive cysteine residues by using a smaller desthiobiotin-...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Nat Biotechnol
Main Authors: Kuljanin, Miljan, Mitchell, Dylan C., Schweppe, Devin K., Gikandi, Ajami S., Nusinow, David P., Bulloch, Nathan J., Vinogradova, Ekaterina V., Wilson, David L., Kool, Eric T., Mancias, Joseph D., Cravatt, Benjamin F., Gygi, Steven P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8316984/
https://ncbi.nlm.nih.gov/pubmed/33398154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41587-020-00778-3
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados