Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries

Current methods used for measuring amino acid side-chain reactivity lack the throughput needed to screen large chemical libraries for interactions across the proteome. Here we redesigned the workflow for activity-based protein profiling of reactive cysteine residues by using a smaller desthiobiotin-...

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Udgivet i:Nat Biotechnol
Main Authors: Kuljanin, Miljan, Mitchell, Dylan C., Schweppe, Devin K., Gikandi, Ajami S., Nusinow, David P., Bulloch, Nathan J., Vinogradova, Ekaterina V., Wilson, David L., Kool, Eric T., Mancias, Joseph D., Cravatt, Benjamin F., Gygi, Steven P.
Format: Artigo
Sprog:Inglês
Udgivet: 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8316984/
https://ncbi.nlm.nih.gov/pubmed/33398154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41587-020-00778-3
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