STING suppresses bone cancer pain via immune and neuronal modulation

Patients with advanced stage cancers frequently suffer from severe pain as a result of bone metastasis and bone destruction, for which there is no efficacious treatment. Here, using multiple mouse models of bone cancer, we report that agonists of the immune regulator STING (stimulator of interferon...

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Bibliografiske detaljer
Udgivet i:Nat Commun
Main Authors: Wang, Kaiyuan, Donnelly, Christopher R., Jiang, Changyu, Liao, Yihan, Luo, Xin, Tao, Xueshu, Bang, Sangsu, McGinnis, Aidan, Lee, Michael, Hilton, Matthew J., Ji, Ru-Rong
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8316360/
https://ncbi.nlm.nih.gov/pubmed/34315904
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-24867-2
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