The molecular context of vulnerability for CDK9 suppression in triple wild-type melanoma

Approximately half of melanoma tumors lack a “druggable” target and are unresponsive to current targeted therapeutics. One proposed approach for treating these therapeutically-orphaned tumors is by targeting transcriptional dependencies (“oncogene starvation”), whereby survival factors are depleted...

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Bibliografiske detaljer
Udgivet i:J Invest Dermatol
Main Authors: Guhan, Samantha M., Shaughnessy, Michael, Rajadurai, Anpuchchelvi, Taylor, Michael, Kumar, Raj, Ji, Zhenyu, Rashid, Sarem, Flaherty, Keith, Tsao, Hensin
Format: Artigo
Sprog:Inglês
Udgivet: 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8316294/
https://ncbi.nlm.nih.gov/pubmed/33745909
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jid.2020.12.035
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