KSHV-encoded vCyclin can modulate HIF1α levels to promote DNA replication in hypoxia

The cellular adaptive response to hypoxia, mediated by high HIF1α levels includes metabolic reprogramming, restricted DNA replication and cell division. In contrast to healthy cells, the genome of cancer cells, and Kaposi’s sarcoma associated herpesvirus (KSHV) infected cells maintains replication i...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:eLife
Prif Awduron: Kumar Singh, Rajnish, Pei, Yonggang, Bose, Dipayan, Lamplugh, Zachary L, Sun, Kunfeng, Yuan, Yan, Lieberman, Paul, You, Jianxin, Robertson, Erle S
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: eLife Sciences Publications, Ltd 2021
Pynciau:
Microbiology and Infectious Disease
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC8315796/
https://ncbi.nlm.nih.gov/pubmed/34279223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.57436
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