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Shugoshin 1 is dislocated by KSHV-encoded LANA inducing aneuploidy
Shugoshin-1 (Sgo1) protects the integrity of the centromeres, and H2A phosphorylation is critical for this process. The mitotic checkpoint kinase Bub1, phosphorylates H2A and ensures fidelity of chromosome segregation and chromosome number. Oncogenic KSHV induces genetic alterations through chromoso...
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| Publicado en: | PLoS Pathog |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Public Library of Science
2018
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6136811/ https://ncbi.nlm.nih.gov/pubmed/30212568 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1007253 |
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