Shugoshin 1 is dislocated by KSHV-encoded LANA inducing aneuploidy

Shugoshin-1 (Sgo1) protects the integrity of the centromeres, and H2A phosphorylation is critical for this process. The mitotic checkpoint kinase Bub1, phosphorylates H2A and ensures fidelity of chromosome segregation and chromosome number. Oncogenic KSHV induces genetic alterations through chromoso...

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Vydáno v:PLoS Pathog
Hlavní autoři: Lang, Fengchao, Sun, Zhiguo, Pei, Yonggang, Singh, Rajnish Kumar, Jha, Hem Chandra, Robertson, Erle S.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2018
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6136811/
https://ncbi.nlm.nih.gov/pubmed/30212568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1007253
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