Shugoshin 1 is dislocated by KSHV-encoded LANA inducing aneuploidy

Shugoshin-1 (Sgo1) protects the integrity of the centromeres, and H2A phosphorylation is critical for this process. The mitotic checkpoint kinase Bub1, phosphorylates H2A and ensures fidelity of chromosome segregation and chromosome number. Oncogenic KSHV induces genetic alterations through chromoso...

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Udgivet i:PLoS Pathog
Main Authors: Lang, Fengchao, Sun, Zhiguo, Pei, Yonggang, Singh, Rajnish Kumar, Jha, Hem Chandra, Robertson, Erle S.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2018
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6136811/
https://ncbi.nlm.nih.gov/pubmed/30212568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1007253
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