G-quadruplex DNA inhibits unwinding activity but promotes liquid–liquid phase separation by the DEAD-box helicase Ded1p

G-quadruplex DNA interacts with the N-terminal intrinsically disordered domain of the DEAD-box helicase Ded1p, diminishing RNA unwinding activity but enhancing liquid–liquid phase separation of Ded1p in vitro and in cells. The data highlight multifaceted effects of quadruplex DNA on an enzyme with i...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Chem Commun (Camb)
Main Authors: Gao, Jun, Gao, Zhaofeng, Putnam, Andrea A., Byrd, Alicia K., Venus, Sarah L., Marecki, John C., Edwards, Andrea D., Lowe, Haley M., Jankowsky, Eckhard, Raney, Kevin D.
Format: Artigo
Jezik:Inglês
Izdano: The Royal Society of Chemistry 2021
Teme:
Chemistry
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC8315639/
https://ncbi.nlm.nih.gov/pubmed/34232232
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/d1cc01479j
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