G-quadruplex DNA inhibits unwinding activity but promotes liquid–liquid phase separation by the DEAD-box helicase Ded1p

G-quadruplex DNA interacts with the N-terminal intrinsically disordered domain of the DEAD-box helicase Ded1p, diminishing RNA unwinding activity but enhancing liquid–liquid phase separation of Ded1p in vitro and in cells. The data highlight multifaceted effects of quadruplex DNA on an enzyme with i...

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Bibliographische Detailangaben
Veröffentlicht in:Chem Commun (Camb)
Hauptverfasser: Gao, Jun, Gao, Zhaofeng, Putnam, Andrea A., Byrd, Alicia K., Venus, Sarah L., Marecki, John C., Edwards, Andrea D., Lowe, Haley M., Jankowsky, Eckhard, Raney, Kevin D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Royal Society of Chemistry 2021
Schlagworte:
Chemistry
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8315639/
https://ncbi.nlm.nih.gov/pubmed/34232232
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/d1cc01479j
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