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Mechanism and Inhibition of Human Methionine Adenosyltransferase 2A
S-Adenosyl-l-methionine (AdoMet) is synthesized by the MAT2A isozyme of methionine adenosyltransferase in most human tissues and in cancers. Its contribution to epigenetic control has made it a target for anticancer intervention. A recent kinetic isotope effect analysis of MAT2A demonstrated a loose...
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| Pubblicato in: | Biochemistry |
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| Autori principali: | , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2021
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8315116/ https://ncbi.nlm.nih.gov/pubmed/33656855 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.0c00998 |
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