2′,6′-Dihalostyrylanilines, Pyridines, and Pyrimidines for the Inhibition of the Catalytic Subunit of Methionine S-Adenosyltransferase-2

[Image: see text] Inhibition of the catalytic subunit of the heterodimeric methionine S-adenosyl transferase-2 (MAT2A) with fluorinated N,N-dialkylaminostilbenes (FIDAS agents) offers a potential avenue for the treatment of liver and colorectal cancers where upregulation of this enzyme occurs. A stu...

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Autors principals: Sviripa, Vitaliy M., Zhang, Wen, Balia, Andrii G., Tsodikov, Oleg V., Nickell, Justin R., Gizard, Florence, Yu, Tianxin, Lee, Eun Y., Dwoskin, Linda P., Liu, Chunming, Watt, David S.
Format: Artigo
Idioma:Inglês
Publicat: American Chemical Society 2014
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4111374/
https://ncbi.nlm.nih.gov/pubmed/24950374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm5004864
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