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Methionine adenosyltransferases in cancers: Mechanisms of dysregulation and implications for therapy

Methionine adenosyltransferase genes encode enzymes responsible for the biosynthesis of S-adenosylmethionine, the principal biological methyl donor and precursor of polyamines and glutathione. Mammalian cells express three genes – MAT1A, MAT2A, and MAT2B – with distinct expression and functions. MAT...

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Bibliografiske detaljer
Udgivet i:Exp Biol Med (Maywood)
Main Authors: Maldonado, Lauren Y, Arsene, Diana, Mato, José M, Lu, Shelly C
Format: Artigo
Sprog:Inglês
Udgivet: SAGE Publications 2017
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5788143/
https://ncbi.nlm.nih.gov/pubmed/29141455
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1535370217740860
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