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Inhibition of Human Methionine Adenosyltransferase 1A Transcription by Coding Region Methylation
Two genes (MAT1A and MAT2A) encode for the essential enzyme methionine adenosyltransferase (MAT). MAT1A is silenced in hepatocellular carcinoma (HCC), and absence of MAT1A leads to spontaneous development of HCC in mice. Previous report correlated promoter methylation to silencing of MAT1A but defin...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2012
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3183271/ https://ncbi.nlm.nih.gov/pubmed/21678410 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcp.22875 |
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