Overexpression of LIMK1 in hippocampal excitatory neurons improves synaptic plasticity and social recognition memory in APP/PS1 mice

Accumulating evidence indicates that the actin regulator cofilin is overactivated in Alzheimer’s Disease (AD), but whether this abnormality contributes to synaptic and cognitive impairments in AD is unclear. In addition, the brain region and cell types involved remain unknown. In this study, we spec...

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Bibliografiske detaljer
Udgivet i:Mol Brain
Main Authors: Zhang, Haiwang, Ben Zablah, Youssif, Liu, An, Lee, Dongju, Zhang, Haorui, Meng, Yanghong, Zhou, Changxi, Liu, Xingde, Wang, Yiming, Jia, Zhengping
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2021
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8314529/
https://ncbi.nlm.nih.gov/pubmed/34315506
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13041-021-00833-3
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