Overexpression of LIMK1 in hippocampal excitatory neurons improves synaptic plasticity and social recognition memory in APP/PS1 mice

Accumulating evidence indicates that the actin regulator cofilin is overactivated in Alzheimer’s Disease (AD), but whether this abnormality contributes to synaptic and cognitive impairments in AD is unclear. In addition, the brain region and cell types involved remain unknown. In this study, we spec...

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Detalhes bibliográficos
Publicado no:Mol Brain
Main Authors: Zhang, Haiwang, Ben Zablah, Youssif, Liu, An, Lee, Dongju, Zhang, Haorui, Meng, Yanghong, Zhou, Changxi, Liu, Xingde, Wang, Yiming, Jia, Zhengping
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2021
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8314529/
https://ncbi.nlm.nih.gov/pubmed/34315506
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13041-021-00833-3
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