A Brownian ratchet model for DNA loop extrusion by the cohesin complex

The cohesin complex topologically encircles DNA to promote sister chromatid cohesion. Alternatively, cohesin extrudes DNA loops, thought to reflect chromatin domain formation. Here, we propose a structure-based model explaining both activities. ATP and DNA binding promote cohesin conformational chan...

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Bibliografiske detaljer
Udgivet i:eLife
Main Authors: Higashi, Torahiko L, Pobegalov, Georgii, Tang, Minzhe, Molodtsov, Maxim I, Uhlmann, Frank
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications, Ltd 2021
Fag:
Chromosomes and Gene Expression
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8313234/
https://ncbi.nlm.nih.gov/pubmed/34309513
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.67530
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