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A Brownian ratchet model for DNA loop extrusion by the cohesin complex
The cohesin complex topologically encircles DNA to promote sister chromatid cohesion. Alternatively, cohesin extrudes DNA loops, thought to reflect chromatin domain formation. Here, we propose a structure-based model explaining both activities. ATP and DNA binding promote cohesin conformational chan...
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| Publicado en: | eLife |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
eLife Sciences Publications, Ltd
2021
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8313234/ https://ncbi.nlm.nih.gov/pubmed/34309513 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.67530 |
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