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A Brownian ratchet model for DNA loop extrusion by the cohesin complex
The cohesin complex topologically encircles DNA to promote sister chromatid cohesion. Alternatively, cohesin extrudes DNA loops, thought to reflect chromatin domain formation. Here, we propose a structure-based model explaining both activities. ATP and DNA binding promote cohesin conformational chan...
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| Pubblicato in: | eLife |
|---|---|
| Autori principali: | , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
eLife Sciences Publications, Ltd
2021
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8313234/ https://ncbi.nlm.nih.gov/pubmed/34309513 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.67530 |
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